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Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl

Conventional cancer therapies are based on preferential killing of tumor cells by DNA damage. Previous work showed that, for certain cell types, loss of integrin-mediated adhesion decreased the apoptotic response to DNA damage because of decreased p53 levels after detachment from the extracellular m...

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Bibliografske podrobnosti
Main Authors: Truong, Tony, Sun, Guizhen, Doorly, Michael, Wang, Jean Y. J., Schwartz, Martin Alexander
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC193552/
https://ncbi.nlm.nih.gov/pubmed/12928501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1635435100
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