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Integrins regulate the apoptotic response to DNA damage through modulation of p53

p53 mediates apoptosis of cells after DNA damage including tumor cells after radiation or chemotherapy. Survival of isolated cancer cells after therapy leads to recurrence of therapy-resistant tumors. We now show that for some melanoma, sarcoma, or fibroblastic cell types that survive without integr...

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Hlavní autoři: Lewis, Jean McArthur, Truong, Tony Nguyen, Schwartz, Martin Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2002
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC122574/
https://ncbi.nlm.nih.gov/pubmed/11904424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.062698499
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