Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis

The inhibition of apoptosis of infected host cells is a well-known but poorly understood function of pathogenic mycobacteria. We show that inactivation of the secA2 gene in Mycobacterium tuberculosis, which encodes a component of a virulence-associated protein secretion system, enhanced the apoptosi...

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Hauptverfasser: Hinchey, Joseph, Lee, Sunhee, Jeon, Bo Y., Basaraba, Randall J., Venkataswamy, Manjunatha M., Chen, Bing, Chan, John, Braunstein, Miriam, Orme, Ian M., Derrick, Steven C., Morris, Sheldon L., Jacobs, William R., Porcelli, Steven A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2007
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934588/
https://ncbi.nlm.nih.gov/pubmed/17671656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31947
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