Lysine Auxotrophy Combined with Deletion of the SecA2 Gene Results in a Safe and Highly Immunogenic Candidate Live Attenuated Vaccine for Tuberculosis

Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a major global health problem, despite the widespread use of the M. bovis Bacille Calmette-Guerin (BCG) vaccine and the availability of drug therapies. In recent years, the high incidence of coinfection of M. tuberculosis and HIV, as wel...

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Detalhes bibliográficos
Main Authors: Hinchey, Joseph, Jeon, Bo Y., Alley, Holly, Chen, Bing, Goldberg, Michael, Derrick, Steven, Morris, Sheldon, Jacobs, William R., Porcelli, Steven A., Lee, Sunhee
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018466/
https://ncbi.nlm.nih.gov/pubmed/21264335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015857
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