Antisense oligonucleotide induced exon skipping and the dystrophin gene transcript: cocktails and chemistries

BACKGROUND: Antisense oligonucleotides (AOs) can interfere with exon recognition and intron removal during pre-mRNA processing, and induce excision of a targeted exon from the mature gene transcript. AOs have been used in vitro and in vivo to redirect dystrophin pre-mRNA processing in human and anim...

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Bibliographic Details
Main Authors: Adams, Abbie M, Harding, Penny L, Iversen, Patrick L, Coleman, Catherine, Fletcher, Sue, Wilton, Steve D
Format: Artigo
Language:Inglês
Published: BioMed Central 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933433/
https://ncbi.nlm.nih.gov/pubmed/17601349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-8-57
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