Stabilization and activation of p53 are regulated independently by different phosphorylation events

Treatment of mouse or human cells with the protein kinase C (PKC) inhibitors H7 or bisindolylmaleimide I induced an increase in the lifetime of p53, leading to its accumulation. In inhibitor-treated cells, p53 translocated to the nuclei and bound to DNA but was not competent to induce transcription....

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Detaylı Bibliyografya
Asıl Yazarlar: Chernov, Mikhail V., Ramana, Chilakamarti V., Adler, Victor V., Stark, George R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 1998
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC19322/
https://ncbi.nlm.nih.gov/pubmed/9482877
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