Regulation of c–myc expression by IFN–γ through Stat1-dependent and -independent pathways

Interferons (IFNs) inhibit cell growth in a Stat1-dependent fashion that involves regulation of c–myc expression. IFN–γ suppresses c–myc in wild-type mouse embryo fibroblasts, but not in Stat1-null cells, where IFNs induce c–myc mRNA rapidly and transiently, thus revealing a novel signaling pathway....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO J
Prif Awduron: Ramana, Chilakamarti V., Grammatikakis, Nicholas, Chernov, Mikhail, Nguyen, Hannah, Goh, Kee Chuan, Williams, Bryan R.G., Stark, George R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2000
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305560/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10637230/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.2.263
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