A natural transactivation mutation in the thyroid hormone β receptor: Impaired interaction with putative transcriptional mediators

The syndrome of resistance to thyroid hormone is characterized by elevated serum free thyroid hormones, failure to suppress pituitary thyrotropin secretion, and variable peripheral refractoriness to hormone action. Here we describe a novel leucine to valine mutation in codon 454 (L454V) of the thyro...

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Hlavní autoři: Collingwood, T. N., Rajanayagam, O., Adams, M., Wagner, R., Cavaillès, V., Kalkhoven, E., Matthews, C., Nystrom, E., Stenlof, K., Lindstedt, G., Tisell, L., Fletterick, R. J., Parker, M. G., Chatterjee, V. K. K.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences of the USA 1997
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC19304/
https://ncbi.nlm.nih.gov/pubmed/8990194
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