A role for helix 3 of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone.

Resistance to thyroid hormone (RTH) has hitherto been associated with thyroid hormone beta receptor (TRbeta) mutations which cluster in two regions (alphaalpha 310-353 and alphaalpha 429-461) of the hormone-binding domain and closely approximate the ligand-binding cavity. Here, we describe a third c...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Collingwood, T N, Wagner, R, Matthews, C H, Clifton-Bligh, R J, Gurnell, M, Rajanayagam, O, Agostini, M, Fletterick, R J, Beck-Peccoz, P, Reinhardt, W, Binder, G, Ranke, M B, Hermus, A, Hesch, R D, Lazarus, J, Newrick, P, Parfitt, V, Raggatt, P, de Zegher, F, Chatterjee, V K
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 1998
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170805/
https://ncbi.nlm.nih.gov/pubmed/9707435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.16.4760
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