A natural transactivation mutation in the thyroid hormone β receptor: Impaired interaction with putative transcriptional mediators

The syndrome of resistance to thyroid hormone is characterized by elevated serum free thyroid hormones, failure to suppress pituitary thyrotropin secretion, and variable peripheral refractoriness to hormone action. Here we describe a novel leucine to valine mutation in codon 454 (L454V) of the thyro...

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Detalhes bibliográficos
Main Authors: Collingwood, T. N., Rajanayagam, O., Adams, M., Wagner, R., Cavaillès, V., Kalkhoven, E., Matthews, C., Nystrom, E., Stenlof, K., Lindstedt, G., Tisell, L., Fletterick, R. J., Parker, M. G., Chatterjee, V. K. K.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC19304/
https://ncbi.nlm.nih.gov/pubmed/8990194
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