In vitro selection of a purine nucleotide-specific hammerheadlike ribozyme

The in vitro selection for an intramolecular AUG-cleaving hammerhead-like ribozyme is described. One of the ribozymes selected was found to cleave after this triplet, both intramolecularly and intermolecularly, with rates comparable to the rate of the native GUC-cleaving hammerhead ribozyme. Althoug...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Vaish, Narendra K., Heaton, Paul A., Fedorova, Olga, Eckstein, Fritz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19281/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9482855/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.5.2158
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