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Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shortened lifespan. Using highly purified hematopoietic stem cells from mice aged 2 to 21 mo, we demonstrate a deficit in function yet an increase in stem cell number with advancing age. Expression analys...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1925137/ https://ncbi.nlm.nih.gov/pubmed/17676974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050201 |
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