Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shortened lifespan. Using highly purified hematopoietic stem cells from mice aged 2 to 21 mo, we demonstrate a deficit in function yet an increase in stem cell number with advancing age. Expression analys...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Chambers, Stuart M, Shaw, Chad A, Gatza, Catherine, Fisk, C. Joseph, Donehower, Lawrence A, Goodell, Margaret A
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2007
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1925137/
https://ncbi.nlm.nih.gov/pubmed/17676974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050201
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk