Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shortened lifespan. Using highly purified hematopoietic stem cells from mice aged 2 to 21 mo, we demonstrate a deficit in function yet an increase in stem cell number with advancing age. Expression analys...

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Autori principali: Chambers, Stuart M, Shaw, Chad A, Gatza, Catherine, Fisk, C. Joseph, Donehower, Lawrence A, Goodell, Margaret A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1925137/
https://ncbi.nlm.nih.gov/pubmed/17676974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050201
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