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The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
A temporal decline in tissue stem cell functionality may be a key component of mammalian aging. The tumor suppressor p53 has recently been implicated as a potential regulator of aging. We examined age-associated hematopoietic stem cell (HSC) dynamics in mice with varying p53 activities. Reduced p53...
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| Główni autorzy: | , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society of Hematology
2007
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1794064/ https://ncbi.nlm.nih.gov/pubmed/17032926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-03-010413 |
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