Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX

The chromatin-associated protein ATRX was originally identified because mutations in the ATRX gene cause a severe form of syndromal X-linked mental retardation associated with α-thalassemia. Half of all of the disease-associated missense mutations cluster in a cysteine-rich region in the N terminus...

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Détails bibliographiques
Auteurs principaux: Argentaro, Anthony, Yang, Ji-Chun, Chapman, Lynda, Kowalczyk, Monika S., Gibbons, Richard J., Higgs, Douglas R., Neuhaus, David, Rhodes, Daniela
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2007
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924575/
https://ncbi.nlm.nih.gov/pubmed/17609377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704057104
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