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In vitro replication and thermodynamic studies of methylation and oxidation modifications of 6-thioguanine
The cytotoxic effects of thiopurine drugs are mostly exerted through the formation of thioguanine nucleotide and its subsequent incorporation into DNA. The 6-thioguanine (6-TG) in DNA can be converted to S(6)-methylthio-2-aminopurine (2-AP-6-SCH(3)) and 2-aminopurine-6-sulfonic acid (2-AP-6-SO(3)H)...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1920245/ https://ncbi.nlm.nih.gov/pubmed/17517786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm247 |
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