Uracil–DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms

DNA glycosylases UNG and SMUG1 excise uracil from DNA and belong to the same protein superfamily. Vertebrates contain both SMUG1 and UNG, but their distinct roles in base excision repair (BER) of deaminated cytosine (U:G) are still not fully defined. Here we have examined the ability of human SMUG1...

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Библиографические подробности
Главные авторы: Pettersen, Henrik Sahlin, Sundheim, Ottar, Gilljam, Karin Margaretha, Slupphaug, Geir, Krokan, Hans Einar, Kavli, Bodil
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2007
Предметы:
Molecular Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1919486/
https://ncbi.nlm.nih.gov/pubmed/17537817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm372
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