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Synthesis and biological evaluation of cytotoxic analogs of somatostatin containing doxorubicin or its intensely potent derivative, 2-pyrrolinodoxorubicin

To create cytotoxic hybrid analogs of somatostatin (SST), octapeptides RC-160 (d-Phe-C [Formula: see text] s-Trp-NH(2)) and RC-121 (d-Phe-C [Formula: see text] s-Thr-NH(2)) were linked to doxorubicin (DOX) or its superactive derivative, 2-pyrrolino-DOX (AN-201). The conjugation was performed by coup...

詳細記述

保存先:
書誌詳細
主要な著者: Nagy, Attila, Schally, Andrew V., Halmos, Gábor, Armatis, Patricia, Cai, Ren-Zhi, Csernus, Valér, Kovács, Magdolna, Koppán, Miklós, Szepesházi, Károly, Kahán, Zsuzsanna
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 1998
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC19192/
https://ncbi.nlm.nih.gov/pubmed/9465096
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