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Synthesis and biological evaluation of cytotoxic analogs of somatostatin containing doxorubicin or its intensely potent derivative, 2-pyrrolinodoxorubicin
To create cytotoxic hybrid analogs of somatostatin (SST), octapeptides RC-160 (d-Phe-C [Formula: see text] s-Trp-NH(2)) and RC-121 (d-Phe-C [Formula: see text] s-Thr-NH(2)) were linked to doxorubicin (DOX) or its superactive derivative, 2-pyrrolino-DOX (AN-201). The conjugation was performed by coup...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The National Academy of Sciences
1998
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC19192/ https://ncbi.nlm.nih.gov/pubmed/9465096 |
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