Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest.

The Vpr protein encoded by human immunodeficiency virus type 1 (HIV-1) is important for growth of virus in macrophages and prevents infected cells from passing into mitosis (G2 arrest). The cellular target for these functions is not known, but Vpr of HIV-1 and the related Vpr from simian immunodefic...

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Main Authors: Selig, L, Benichou, S, Rogel, M E, Wu, L I, Vodicka, M A, Sire, J, Benarous, R, Emerman, M
Formato: Artigo
Idioma:Inglês
Publicado: 1997
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC191711/
https://ncbi.nlm.nih.gov/pubmed/9151883
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