Requirement for Uracil-DNA Glycosylase during the Transition to Late-Phase Cytomegalovirus DNA Replication

Cytomegalovirus gene UL114, a homolog of mammalian uracil-DNA glycosylase (UNG), is required for efficient viral DNA replication. In quiescent fibroblasts, UNG mutant virus replication is delayed for 48 h and follows the virus-induced expression of cellular UNG. In contrast, mutant virus replication...

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Detalhes bibliográficos
Main Authors: Courcelle, Charmain Tan, Courcelle, Justin, Prichard, Mark N., Mocarski, Edward S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114994/
https://ncbi.nlm.nih.gov/pubmed/11462031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.16.7592-7601.2001
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