Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase.

Two different crystal structures of the human immunodeficiency virus type 1 (HIV-1) integrase (IN) catalytic domain were analyzed for interactions at the enzyme active site. Gln-62 and Glu-92 interact with active-site residue Asp-64, and Lys-136 interacts with active-site residue Asp-116 across a di...

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Pubblicato in:	J Virol
Autori principali:	Engelman, A, Liu, Y, Chen, H, Farzan, M, Dyda, F
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191497/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9094622/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.5.3507-3514.1997
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