Initial appearance of the 184Ile variant in lamivudine-treated patients is caused by the mutational bias of human immunodeficiency virus type 1 reverse transcriptase.

Treatment of human immunodeficiency virus type 1-infected patients with lamivudine (3TC) results in the appearance of drug-resistant virus variants with a mutation at the 184Met codon (ATG) of the reverse transcriptase (RT) gene. The 184Ile (ATA) variant appears first, but subsequently the 184Val (G...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Keulen, W, Back, N K, van Wijk, A, Boucher, C A, Berkhout, B
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191477/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9060708/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.4.3346-3350.1997
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