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Initial appearance of the 184Ile variant in lamivudine-treated patients is caused by the mutational bias of human immunodeficiency virus type 1 reverse transcriptase.

Treatment of human immunodeficiency virus type 1-infected patients with lamivudine (3TC) results in the appearance of drug-resistant virus variants with a mutation at the 184Met codon (ATG) of the reverse transcriptase (RT) gene. The 184Ile (ATA) variant appears first, but subsequently the 184Val (G...

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Bibliografiska uppgifter
Huvudupphovsmän: Keulen, W, Back, N K, van Wijk, A, Boucher, C A, Berkhout, B
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1997
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC191477/
https://ncbi.nlm.nih.gov/pubmed/9060708
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