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Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS

Many disease-related processes occur via protein complexes that are considered undruggable with small molecules. An example is RAS, which is frequently mutated in cancer and contributes to initiation and maintenance of the disease by constitutive signal transduction through protein interaction with...

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Hlavní autoři: Tanaka, Tomoyuki, Williams, Roger L, Rabbitts, Terence H
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1914092/
https://ncbi.nlm.nih.gov/pubmed/17568777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601744
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