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Pan RAS-binding compounds selected from a chemical library by inhibiting interaction between RAS and a reduced affinity intracellular antibody

Intracellular antibodies are valuable tools for target validation studies for clinical situations such as cancer. Recently we have shown that antibodies can be used for drug discovery in screening for chemical compounds surrogates by showing that compounds could be developed to the so-called undrugg...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Tanaka, Tomoyuki, Thomas, Jemima, Van Montfort, Rob, Miller, Ami, Rabbitts, Terry
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814043/
https://ncbi.nlm.nih.gov/pubmed/33462327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81262-z
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