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Pan RAS-binding compounds selected from a chemical library by inhibiting interaction between RAS and a reduced affinity intracellular antibody

Intracellular antibodies are valuable tools for target validation studies for clinical situations such as cancer. Recently we have shown that antibodies can be used for drug discovery in screening for chemical compounds surrogates by showing that compounds could be developed to the so-called undrugg...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Tanaka, Tomoyuki, Thomas, Jemima, Van Montfort, Rob, Miller, Ami, Rabbitts, Terry
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814043/
https://ncbi.nlm.nih.gov/pubmed/33462327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81262-z
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