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Cancer cell killing by target antigen engagement with engineered complementary intracellular antibody single domains fused to pro-caspase3

Many tumour causing proteins, such as those expressed after chromosomal translocations or from point mutations, are intracellular and are not enzymes per se amenable to conventional drug targeting. We previously demonstrated an approach (Antibody-antigen Interaction Dependent Apoptosis (AIDA)) where...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chambers, Jennifer S., Brend, Tim, Rabbitts, Terence H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561968/
https://ncbi.nlm.nih.gov/pubmed/31189945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44908-7
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