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Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4

It has been proposed that the cleaved form of protease-activated receptor 3 (PAR3) acts as a cofactor for thrombin cleavage and activation of PAR4 on murine platelets, but the molecular basis of this physiologically important effect remains elusive. X-ray crystal structures of murine thrombin bound...

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Hlavní autoři: Bah, Alaji, Chen, Zhiwei, Bush-Pelc, Leslie A., Mathews, F. Scott, Di Cera, Enrico
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913866/
https://ncbi.nlm.nih.gov/pubmed/17606903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704409104
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