Effect of the E4 region on the persistence of transgene expression from adenovirus vectors.

The utility of adenovirus vectors for gene therapy is limited by the transience of expression that has been observed in various in vivo models. Immunological responses to viral targets can eliminate transduced cells and cause the loss of transgene expression. We previously described the characteriza...

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Pubblicato in:	J Virol
Autori principali:	Armentano, D, Zabner, J, Sacks, C, Sookdeo, C C, Smith, M P, St George, J A, Wadsworth, S C, Smith, A E, Gregory, R J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191351/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9032378/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.3.2408-2416.1997
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