Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content

We hypothesized that overexpression of PDGF-BB in colorectal cancer (CRC) and pancreatic cancer cells would result in increased pericyte coverage of ECs in vivo, rendering the tumor vasculature more resistant to antiangiogenic therapy. We stably transfected the cDNA for the PDGF-B into HT-29 human C...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: McCarty, Marya F., Somcio, Ray J., Stoeltzing, Oliver, Wey, Jane, Fan, Fan, Liu, Wenbiao, Bucana, Corazon, Ellis, Lee M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2007
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913488/
https://ncbi.nlm.nih.gov/pubmed/17641778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31334
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