Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content

We hypothesized that overexpression of PDGF-BB in colorectal cancer (CRC) and pancreatic cancer cells would result in increased pericyte coverage of ECs in vivo, rendering the tumor vasculature more resistant to antiangiogenic therapy. We stably transfected the cDNA for the PDGF-B into HT-29 human C...

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Autori principali: McCarty, Marya F., Somcio, Ray J., Stoeltzing, Oliver, Wey, Jane, Fan, Fan, Liu, Wenbiao, Bucana, Corazon, Ellis, Lee M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913488/
https://ncbi.nlm.nih.gov/pubmed/17641778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31334
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