Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content

We hypothesized that overexpression of PDGF-BB in colorectal cancer (CRC) and pancreatic cancer cells would result in increased pericyte coverage of ECs in vivo, rendering the tumor vasculature more resistant to antiangiogenic therapy. We stably transfected the cDNA for the PDGF-B into HT-29 human C...

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Bibliografiske detaljer
Main Authors: McCarty, Marya F., Somcio, Ray J., Stoeltzing, Oliver, Wey, Jane, Fan, Fan, Liu, Wenbiao, Bucana, Corazon, Ellis, Lee M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913488/
https://ncbi.nlm.nih.gov/pubmed/17641778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31334
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