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Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content
We hypothesized that overexpression of PDGF-BB in colorectal cancer (CRC) and pancreatic cancer cells would result in increased pericyte coverage of ECs in vivo, rendering the tumor vasculature more resistant to antiangiogenic therapy. We stably transfected the cDNA for the PDGF-B into HT-29 human C...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1913488/ https://ncbi.nlm.nih.gov/pubmed/17641778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31334 |
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