Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells

Neuropilin-1 (NRP-1) is a novel co-receptor for vascular endothelial growth factor (VEGF). Neuropilin-1 is expressed in pancreatic cancer, but not in nonmalignant pancreatic tissue. We hypothesised that NRP-1 expression by pancreatic cancer cells contributes to the malignant phenotype. To determine...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wey, J S, Gray, M J, Fan, F, Belcheva, A, McCarty, M F, Stoeltzing, O, Somcio, R, Liu, W, Evans, D B, Klagsbrun, M, Gallick, G E, Ellis, L M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2005
Schlagworte:
Molecular Diagnostics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361553/
https://ncbi.nlm.nih.gov/pubmed/15956974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602663
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