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Mediating ERK1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome
Noonan syndrome (NS) is an autosomal dominant disorder characterized by a wide spectrum of defects, which most frequently include proportionate short stature, craniofacial anomalies, and congenital heart disease (CHD). NS is the most common nonchromosomal cause of CHD, and 80%–90% of NS patients hav...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1913487/ https://ncbi.nlm.nih.gov/pubmed/17641779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30756 |
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