A novel Met-to-Thr mutation in the YMDD motif of reverse transcriptase from feline immunodeficiency virus confers resistance to oxathiolane nucleosides.

Variants of feline immunodeficiency virus (FIV) that possess a unique methionine-to-threonine mutation within the YMDD motif of reverse transcriptase (RT) were selected by culturing virus in the presence of inhibitory concentrations of (-)-beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine...

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Main Authors: Smith, R A, Remington, K M, Lloyd, R M, Schinazi, R F, North, T W
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC191345/
https://ncbi.nlm.nih.gov/pubmed/9032372
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