A novel Met-to-Thr mutation in the YMDD motif of reverse transcriptase from feline immunodeficiency virus confers resistance to oxathiolane nucleosides.

Variants of feline immunodeficiency virus (FIV) that possess a unique methionine-to-threonine mutation within the YMDD motif of reverse transcriptase (RT) were selected by culturing virus in the presence of inhibitory concentrations of (-)-beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine [(-)-FTC]. The...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Smith, R A, Remington, K M, Lloyd, R M, Schinazi, R F, North, T W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191345/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9032372/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.3.2357-2362.1997
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