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Roles of rapH and rapG in Positive Regulation of Rapamycin Biosynthesis in Streptomyces hygroscopicus

Rapamycin is an important macrocyclic polyketide produced by Streptomyces hygroscopicus and showing immunosuppressive, antifungal, and antitumor activities as well as displaying anti-inflammatory and neuroregenerative properties. The immense pharmacological potential of rapamycin has led to the prod...

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Détails bibliographiques
Auteurs principaux: Kuščer, Enej, Coates, Nigel, Challis, Iain, Gregory, Matt, Wilkinson, Barrie, Sheridan, Rose, Petković, Hrvoje
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913445/
https://ncbi.nlm.nih.gov/pubmed/17468238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00129-07
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