In Vitro Resistance Selection and In Vivo Efficacy of Morpholino Oligomers against West Nile Virus

We characterize in vitro resistance to and demonstrate the in vivo efficacy of two antisense phosphorodiamidate morpholino oligomers (PMOs) against West Nile virus (WNV). Both PMOs were conjugated with an Arg-rich peptide. One peptide-conjugated PMO (PPMO) binds to the 5′ terminus of the viral genom...

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Bibliografische gegevens
Hoofdauteurs: Deas, Tia S., Bennett, Corey J., Jones, Susan A., Tilgner, Mark, Ren, Ping, Behr, Melissa J., Stein, David A., Iversen, Patrick L., Kramer, Laura D., Bernard, Kristen A., Shi, Pei-Yong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2007
Onderwerpen:
Antiviral Agents
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913242/
https://ncbi.nlm.nih.gov/pubmed/17485503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00069-07
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