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In Vitro Resistance Selection and In Vivo Efficacy of Morpholino Oligomers against West Nile Virus
We characterize in vitro resistance to and demonstrate the in vivo efficacy of two antisense phosphorodiamidate morpholino oligomers (PMOs) against West Nile virus (WNV). Both PMOs were conjugated with an Arg-rich peptide. One peptide-conjugated PMO (PPMO) binds to the 5′ terminus of the viral genom...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Microbiology (ASM)
2007
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1913242/ https://ncbi.nlm.nih.gov/pubmed/17485503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00069-07 |
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