Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil.

1. The fungal metabolite, wortmannin, has recently been shown to inhibit fMet-Leu-Phe-stimulated superoxide production and phospholipase D (PLD) activation in the human neutrophil. 2. We have found that a close structural analogue of wortmannin, demethoxyviridin, has a similar inhibitory profile but...

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Autors principals: Bonser, R. W., Thompson, N. T., Randall, R. W., Tateson, J. E., Spacey, G. D., Hodson, H. F., Garland, L. G.
Format: Artigo
Idioma:Inglês
Publicat: 1991
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1908105/
https://ncbi.nlm.nih.gov/pubmed/1908735
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