Tumour necrosis factor (TNF) production by T cell receptor-primed T lymphocytes is a target for low dose methotrexate in rheumatoid arthritis

Methotrexate (MTX) is an effective immunosuppressive agent in various chronic inflammatory diseases such as rheumatoid arthritis (RA). However, its mechanisms of action are only partially understood. In this study, we assessed the effects of MTX on the differentiation of peripheral blood (PB) CD4(+)...

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Autors principals: Hildner, K, Finotto, S, Becker, C, Schlaak, J, Schirmacher, P, Galle, P R, Märker-Hermann, E, Neurath, M F
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 1999
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905404/
https://ncbi.nlm.nih.gov/pubmed/10540171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1999.01022.x
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