Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression

Immunosuppressive therapy with methotrexate (MTX) has been established as effective treatment for patients with rheumatoid arthritis. To analyse the therapeutic potential and mechanisms of action of MTX, we determined serum cytokine levels and cytokine production by splenic T cells and macrophages i...

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Detalhes bibliográficos
Main Authors: Neurath, M F, Hildner, K, Becker, C, Schlaak, J F, Barbulescu, K, Germann, T, Schmitt, E, Schirmacher, P, Haralambous, S, Pasparakis, M, Meyer Zum BÜschenfelde, K-H, Kollias, G, MÄrker-Hermann, E
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1999
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905174/
https://ncbi.nlm.nih.gov/pubmed/9933419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1999.00753.x
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