Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression

Immunosuppressive therapy with methotrexate (MTX) has been established as effective treatment for patients with rheumatoid arthritis. To analyse the therapeutic potential and mechanisms of action of MTX, we determined serum cytokine levels and cytokine production by splenic T cells and macrophages i...

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Bibliographic Details
Main Authors: Neurath, M F, Hildner, K, Becker, C, Schlaak, J F, Barbulescu, K, Germann, T, Schmitt, E, Schirmacher, P, Haralambous, S, Pasparakis, M, Meyer Zum BÜschenfelde, K-H, Kollias, G, MÄrker-Hermann, E
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 1999
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905174/
https://ncbi.nlm.nih.gov/pubmed/9933419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1999.00753.x
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