The in vivo induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720

The in vitro treatment of lpr thymocytes with FTY720 resulted in a dose-dependent reduction in cell viability due to apoptosis. In order to study the effect of FTY720 in vivo, lpr mice received an oral daily dose of 1 mg/kg FTY720 for 14 days, beginning at 16 weeks of age which was when the animals...

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Bibliografiske detaljer
Main Authors: SUZUKI, S, LI, X -K, SHINOMIYA, T, ENOSAWA, S, AMEMIYA, H, AMARI, M, NAOE, S
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 1997
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904563/
https://ncbi.nlm.nih.gov/pubmed/9010264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1997.d01-885.x
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