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Biochemical characterization of the fidelity of poliovirus RNA-dependent RNA polymerase

BACKGROUND: Putative high mutation rates of RNA viruses are believed to mediate undesirable phenomena, such as emergence of drug resistance. However, very little is known about biochemical fidelity rates for viral RNA-dependent RNA polymerases. Using a recently developed in vitro polymerase assay fo...

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Библиографические подробности
Главные авторы: Freistadt, Marion S, Vaccaro, Joseph A, Eberle, Karen E
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2007
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904441/
https://ncbi.nlm.nih.gov/pubmed/17524144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-4-44
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