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Biochemical characterization of the fidelity of poliovirus RNA-dependent RNA polymerase

BACKGROUND: Putative high mutation rates of RNA viruses are believed to mediate undesirable phenomena, such as emergence of drug resistance. However, very little is known about biochemical fidelity rates for viral RNA-dependent RNA polymerases. Using a recently developed in vitro polymerase assay fo...

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書誌詳細
主要な著者: Freistadt, Marion S, Vaccaro, Joseph A, Eberle, Karen E
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904441/
https://ncbi.nlm.nih.gov/pubmed/17524144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-4-44
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