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Haploinsufficiency of Yeast FEN1 Causes Instability of Expanded CAG/CTG Tracts in a Length-Dependent Manner
Trinucleotide repeat diseases, such as Huntington's disease, are caused by the expansion of trinucleotide repeats above a threshold of about 35 repeats. Once expanded, the repeats are unstable and tend to expand further both in somatic cells and during transmission, resulting in a more severe d...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2007
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1904339/ https://ncbi.nlm.nih.gov/pubmed/17383831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2007.01.025 |
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