Rational design of an estrogen receptor mutant with altered DNA-binding specificity

Although artificial C2-H2 zinc fingers can be designed to recognize specific DNA sequences, it remains unclear to which extent nuclear receptor C4 zinc fingers can be tailored to bind novel DNA elements. Steroid receptors bind as dimers to palindromic response elements differing in the two central b...

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Autors principals: Nguyen, Denis, Bail, Martine, Pesant, Genevieve, Dupont, Virginie N., Rouault, Étienne, Deschênes, Julie, Rocha, Walter, Melançon, Geneviève, Steinberg, Sergey V., Mader, Sylvie
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2007
Matèries:
Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904296/
https://ncbi.nlm.nih.gov/pubmed/17478511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm241
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