The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted

In pulmonary arterial hypertension (PAH), antiapoptotic, proliferative, and inflammatory diatheses converge to create an obstructive vasculopathy. A selective down-regulation of the Kv channel Kv1.5 has been described in human and animal PAH. The resultant increase in intracellular free Ca(2+) ([Ca(...

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Main Authors: Bonnet, Sebastien, Rochefort, Gael, Sutendra, Gopinath, Archer, Stephen L., Haromy, Alois, Webster, Linda, Hashimoto, Kyoko, Bonnet, Sandra N., Michelakis, Evangelos D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2007
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1903339/
https://ncbi.nlm.nih.gov/pubmed/17596340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610467104
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