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The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted
In pulmonary arterial hypertension (PAH), antiapoptotic, proliferative, and inflammatory diatheses converge to create an obstructive vasculopathy. A selective down-regulation of the Kv channel Kv1.5 has been described in human and animal PAH. The resultant increase in intracellular free Ca(2+) ([Ca(...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1903339/ https://ncbi.nlm.nih.gov/pubmed/17596340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610467104 |
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