Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is characterized by genetic and acquired abnormalities that suppress apoptosis and enhance cell proliferation in the vascular wall, including downregulation of the bone morphogenetic protein axis and voltage-gated K(+) (Kv) channels. Survivin is an “inhibitor of...

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Bibliografiska uppgifter
Huvudupphovsmän: McMurtry, M. Sean, Archer, Stephen L., Altieri, Dario C., Bonnet, Sebastien, Haromy, Alois, Harry, Gwyneth, Bonnet, Sandra, Puttagunta, Lakshmi, Michelakis, Evangelos D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2005
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136986/
https://ncbi.nlm.nih.gov/pubmed/15931388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI23203
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