Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57(KIP2 )requires binding to proliferating cell nuclear antigen

Proper control of the mammalian cell cycle requires the function of cyclin-dependent kinase (CDK) inhibitors. The p21 family currently includes three distinct genes, p21, p27(Kip1), and p57(Kip2), that share a common N-terminal domain for binding to and inhibiting the kinase activity of CDK-cyclin c...

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Main Authors: Watanabe, Hiroyuki, Pan, Zhen-Qiang, Schreiber-Agus, Nicole, DePinho, Ronald A., Hurwitz, Jerard, Xiong, Yue
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1998
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC19016/
https://ncbi.nlm.nih.gov/pubmed/9465025
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