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p57(Kip2) Stabilizes the MyoD Protein by Inhibiting Cyclin E-Cdk2 Kinase Activity in Growing Myoblasts

We show that expression of p57(Kip2), a potent tight-binding inhibitor of several G(1) cyclin–cyclin-dependent kinase (Cdk) complexes, increases markedly during C2C12 myoblast differentiation. We examined the effect of p57(Kip2) on the activity of the transcription factor MyoD. In transient transfec...

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Detalhes bibliográficos
Main Authors: Reynaud, Emmanuel G., Pelpel, Karine, Guillier, Martine, Leibovitch, Marie Pierre, Leibovitch, Serge A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC84790/
https://ncbi.nlm.nih.gov/pubmed/10523650
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